DOI: 10.1039/d6md00545d ISSN: 2632-8682
Simultaneous exploitation of phaeanthine – a bisbenzylisoquinoline alkaloid for dual anti-metastatic and anti-angiogenic potential by disruption of Akt/NF-κB/MMP regulatory pathways
Alisha Valsan, Vishnu priya Murali, Murugan Thulasi Meenu, Anuja Gracy Joseph, Kokkuvayil Vasu Radhakrishnan, Daisy R. Sherin, Kaustabh Kumar MaitiPhaeanthine (PHA) exerts anti-metastatic and anti-angiogenic effects by modulating Akt/NF-κB/HIF-1α/MMP expressions, reversing EMT, suppressing ECM remodeling and tube formation, with docking data supporting PHA-MMP-2/9 binding.