Sex Differences in the Association Between the Systemic Immune‐Inflammation Index and Coronary Lesion Severity in Acute Coronary Syndrome
Ming Hong, Chuntian Wang, Hui Liu, Yan Huai, Jiangying Kuang, Huiqiang ChenABSTRACT
Background
Elevated systemic immune‐inflammation index (SII) correlates with increased coronary artery disease (CAD) prevalence and severity in acute coronary syndrome (ACS). The aim of this study was to evaluate the influence of sex on SII and its association with coronary stenosis in ACS.
Methods
A total of 130 patients with ACS, who had performed coronary angiography, were enrolled. Gensini Score (GS) was used to reflect the degree of coronary stenosis. The association of SII and GS were studied.
Results
The mean values of SII and GS were significantly higher ( p = 0.048 and 0.001, respectively) in male individuals compared with female counterparts. There was a significant correlation between SII and GS ( r = 0.306, p = 0.006) in male participants. However, the positive correlation between SII and GS was not found in female subjects. SII was independently associated with GS ( B = 0.030, p = 0.007) after controlling for age, smoking, and low‐density lipoprotein cholesterol (LDL‐C) in male participants. LDL‐C ( B = 11.741, p = 0.003), smoking ( B = 39.018, p = 0.016) and age ( B = 1.139, p = 0.030), but not SII ( B = 0.027, p = 0.101) were found to be independently correlated with the degree of coronary stenosis in females.
Conclusions
SII was a associated marker for evaluating the extent of coronary lesions in male subjects with ACS, but not in female counterparts.