DOI: 10.1093/bjd/ljag478 ISSN: 0007-0963
Serum Proteomic Profiling by Olink Reveal Identifies Stage-Dependent and Progression-Associated Biomarkers in Mycosis Fungoides
Myoung Eun Choi, Jihyeon Kim, Joon Min Jung, Chong Hyun Won, Sung Eun Chang, Mi Woo Lee, Kyunggon Kim, Woo Jin LeeUsing high-plex serum proteomics, we identified stage-dependent protein signatures across patch, plaque, and tumor stages of mycosis fungoides, with ADAM22 and LRRN1 showing consistent downregulation throughout disease progression. Within the plaque stage, serum proteomic profiles robustly distinguished progressive from indolent disease, with interleukin-32 and PARP1 emerging as the top discriminating biomarkers. An 11-protein predictive panel achieved an area under the curve of 0.952, supporting the feasibility of non-invasive blood-based risk stratification in plaque-stage mycosis fungoides.