DOI: 10.2459/jcm.0000000000001530 ISSN:

Serum albumin and prognosis in elderly patients with nonischemic dilated cardiomyopathy

Xinyi Li, Xiaonan Zhang, Zhigang Zeng, Wenzhi Mai, Zishan Peng, Binjia Li, Wanzi Hong, Yaoxin Liu, Fen Shu, Jiehua Tang, Lishu Xu, Ning Tan, Jinjin Ma, Lei Jiang
  • Cardiology and Cardiovascular Medicine
  • General Medicine
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Aims

Hypoalbuminemia was extensively used to diagnose malnutrition in older adults. Malnutrition was associated with mortality in elderly patients with cardiovascular diseases. The relationship between hypoalbuminemia and clinical outcomes in elderly patients with nonischemic dilated cardiomyopathy (NIDCM) remains unknown.

Methods

A total of 1058 consecutive patients with NIDCM (age ≥60 years) were retrospectively enrolled from January 2010 to December 2019. Univariate and multivariate analyses were performed to assess the association of hypoalbuminemia with clinical outcomes.

Results

Patients with hypoalbuminemia were older (69.29 ± 6.67 vs. 67.61 ± 5.90 years, P < 0.001) and had higher prevalence of in-hospital and long-term death than those without (6.9 vs. 1.7%, 50.7 vs. 35.2%, P < 0.001). Logistic regression analysis showed that hypoalbuminemia was significantly related to in-hospital death [odds ratio (OR): 4.334, 95% confidence interval (CI): 2.185–8.597, P < 0.001]. Kaplan–Meier survival analysis showed that patients with hypoalbuminemia had worse prognosis than those with nonhypoalbuminemia (log-rank χ 2 28.96, P < 0.001). After adjusting for age, serum creatinine, HDL-C, AST/ALT hypoalbuminemia, LVEF and diabetes, hypoalbuminemia remained an independent predictor for long-term death (hazard ratio 1.322, 95% CI 0.046–1.670, P = 0.019).

Conclusion

Hypoalbuminemia was associated with increased risk of in-hospital and long-term mortality in elderly patients with NIDCM.

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