DOI: 10.4103/ijemcr.ijemcr_56_25 ISSN: 2950-4570
Sertoli–Leydig cell tumor in androgen insensitivity syndrome: A case report and review of the literature
Karthik Subramaniam, Jyothi Karikkanthra, Janemary JeesemonABSTRACT
Complete androgen insensitivity syndrome (CAIS) is caused by defective functioning of the androgen receptor in the 46 XY genotype, resulting in a variable extent of feminizing features. However, since the gonad (testis) is functional and is on overdrive, hyperplasia of Sertoli cells is common. Here, we report a case of Sertoli–Leydig cell tumor detected incidentally during gonadectomy of a girl with CAIS. In the literature review, although hyperplasia was commonly reported, tumors were relatively rare.