SEROPREVALENCE OF BIOLOGICAL MARKERS IN PATIENTS WITH OPTIC NEURITIS
Mathew Savio, Moushumi Majumder- General Medicine
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Optic neuritis is inflammation of the optic nerve.There are usually a variety of causes leading to optic neuritis and it is usually difficult to find the exact cause from the local signs and symptoms.There are many cases of optic neuritis that is unrelated to MS. Two novel biomarkers, Aquaporin-4 (AQP4-IgG) and Myelin oligodendrocyte glycoprotein (MOGIgG), have been found in the past that were found to be linked to be linked to atypical optic neuritis.The present study was carried out in 56 eyes of 43 consecutive patients who presented to the outpatient department of Assam Medical College & Hospital, Dibrugarh during the period of July 2020 to June 2021. These patients were examined for various signs as well as microbiological tests were done to detect these antibodies.Antibody against Aquaporin-4 was positive in 3 patients in the present study accounting to 6.98%.The patients who were seronegative for Aquaporin-4 were tested for antibody against MOG and none of the patients were found to be seropositive for the same.