Sensitive and derivatization-free amino acid analysis using liquid chromatography-Raman spectroscopy

doi:10.1039/d6an00841k

DOI: 10.1039/d6an00841k ISSN: 0003-2654

Sensitive and derivatization-free amino acid analysis using liquid chromatography-Raman spectroscopy

Kana Matsuoka, Masahiro Ando, Takuji Nakashima, Haruko Takeyama

LC-Raman spectroscopy with post-column spotting and solvent evaporation enables derivatization-free amino acid detection, molecular identification by intrinsic Raman fingerprints, and quantitative determination in culture medium.

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