DOI: 10.1039/d6ob00965d ISSN: 1477-0520
Semisynthetic diversification of the fungal azaphilone austdiol highlights scaffold-encoded reactivity in natural products
Stefan Valter, Scott Minns, Andrew Crombie, Daniel Vuong, Paul Malek Mirzayans, John A. Kalaitzis, Ernest Lacey, Andrew M. PiggottAustdiol exemplifies how Nature encodes latent reactivity into natural products, enabling non-enzymatic diversification of a single scaffold into structurally diverse analogues.