DOI: 10.1126/science.281.5385.2013 ISSN:

Semiconductor Nanocrystals as Fluorescent Biological Labels

Marcel Bruchez, Mario Moronne, Peter Gin, Shimon Weiss, A. Paul Alivisatos
  • Multidisciplinary

Semiconductor nanocrystals were prepared for use as fluorescent probes in biological staining and diagnostics. Compared with conventional fluorophores, the nanocrystals have a narrow, tunable, symmetric emission spectrum and are photochemically stable. The advantages of the broad, continuous excitation spectrum were demonstrated in a dual-emission, single-excitation labeling experiment on mouse fibroblasts. These nanocrystal probes are thus complementary and in some cases may be superior to existing fluorophores.

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