DOI: 10.1039/d3md00288h ISSN:
Screening and optimization of phage display cyclic peptides against the WDR5 WBM site
Lingyu Song, Jiawen Cao, Lin Chen, Zhiyan Du, Naixia Zhang, Danyan Cao, Bing Xiong- Organic Chemistry
- Drug Discovery
- Pharmaceutical Science
- Pharmacology
- Molecular Medicine
- Biochemistry
We reported two improved screenings based on the phage display technique to discover novel peptidic inhibitors against the WDR5 WBM site, and the optimized cyclic peptide CYC3 was acquired, which could be subjected to further biological evaluation.