ALOX15 links lipid metabolism to receptor trafficking in platelet activation

Platelet activation is traditionally viewed as a signaling process initiated by receptor engagement. In this issue of The FEBS Journal , Govatati et al. identify an additional regulatory layer linking lipid metabolism to receptor trafficking. The authors show that ALOX15‐derived lipid mediators promote PKCθ‐NMT1‐dependent myristoylation of PAR4, thereby facilitating its membrane localization and platelet activation. These findings position receptor lipidation and trafficking as active regulatory mechanisms in platelet activation and suggest new opportunities for therapeutic modulation of hemostasis.