DOI: 10.1093/ijnp/pyad053 ISSN:

Schizophrenia patients discharged on clozapine plus long-acting injectable antipsychotics from a public psychiatric hospital in Taiwan, 2006-2021

Ta-Chun Lin, Ching-Hua Lin
  • Pharmacology (medical)
  • Psychiatry and Mental health
  • Pharmacology



Some schizophrenia patients treated with clozapine experience an inadequate response and adherence problems. The purpose of this study was to compare time to rehospitalization within 6 months in schizophrenia patients discharged on three clozapine regimens. Additionally, the temporal trend of prescription rate in each group was also explored.


Schizophrenia patients discharged from the study hospital from January 1, 2006, to December 31, 2021, (n = 3,271) were included in the analysis. The type of clozapine prescribed at discharge was divided into three groups: clozapine plus long-acting injectable antipsychotics (clozapine + LAIs), clozapine plus other oral antipsychotics (clozapine + OAPs), and clozapine monotherapy. Survival analysis was used to compare time to rehospitalization within 6 months after discharge among the three groups. The temporal trend in the prescription rate of each group was analyzed using the Cochran-Armitage Trend test.


Patients discharged on clozapine + LAIs had a significantly longer time to rehospitalization than those on clozapine + OAPs or clozapine monotherapy. The prescription rates of clozapine + LAIs and clozapine + OAPs significantly increased over time, whereas the prescription rates of clozapine monotherapy significantly decreased.


Compared with clozapine + OAPs group, clozapine + LAIs group had a lower risk of rehospitalization and a lower dose of clozapine prescribed. Therefore, if a second antipsychotic is required for patients who are taking clozapine alone, LAIs should be considered earlier.

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