Outline
DOI: 10.1055/a-2985-5895 ISSN: 0936-5214
Scalable and Catalytic Asymmetric Synthesis of Atorvastatin from Chiral β-lactone
Liang Shi, Yuanhao Dai, Jiayi Song, Renfei Tang, Li Ren, hongdong haoA catalytic asymmetric synthesis of atorvastatin is reported.Key to the success of this synthetic pathway including cinchona alkaloid-catalyzed acid chloride-aldehyde cyclocondensation (AAC) reaction to construct chiral β-lactone, followed by efficient construct 1,3-syn diol through Claisen condensation and Narasaka-Prasad reduction. Subsequent Fukuyama amine synthesis and pyrrole ring formation complete the total synthesis of atorvastatin.
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