ROS‐Balancing MXene/MoSe ₂ Hybrids Combat Drug‐Resistant Bacteria and Accelerate Tissue Regeneration in Cutaneous Wounds

ABSTRACT

Multidrug‐resistant (MDR) bacterial infections and persistent oxidative stress exert a prolonged, hostile inflammatory pressure in chronic skin wounds, posing a formidable clinical challenge. Current antibiotic‐based modalities often fall short in inflammation resolution and cutaneous regeneration. Here, we present the design of a reactive oxygen species (ROS)‐balancing MXene/MoSe ₂ (MX/Mo), with MoSe ₂ synthesized on MXene surfaces via a solvothermal method. In infections, MX/Mo under ultrasound activation promotes efficient electron‐hole separation to trigger a localized ROS storm. This disturbs the bacterial respiratory chain and irreversibly blocks adenosine triphosphate synthesis, causing lethal energy deprivation and MDR bacterial eradication. During healing, MX/Mo without ultrasound exhibits significant multienzyme‐like activity to autonomously scavenge residual ROS, alleviating oxidative injury. In in vivo studies, MX/Mo exhibits superior antibacterial and wound healing efficacy by rapidly suppressing severe Methicillin‐resistant Staphylococcus aureus infections and creating a favorable microenvironment with balanced ROS levels, thereby triggering angiogenesis and promoting collagen deposition for tissue regeneration. We anticipate that MX/Mo addresses skin wounds with multifactorial pathologies by integrating antibacterial activity and oxidative stress regulation, which offers new possibilities for treating a broad range of bacterial infection‐driven disorders.