Role of triple antibiotic paste in treatment of immature necrotic teeth

The development and progression of periapical lesions are associated with the presence of both aerobic and anaerobic bacteria. Immature teeth with apical periodontitis complicate this problem. A combination of antibiotic drugs (metronidazole, ciprofloxacin, and minocycline) is used to eliminate target bacteria, which are the possible sources of endodontic lesions. These case reports describe the treatment of immature teeth with large periradicular lesions using triple antibiotic paste. The follow-up radiograph of both cases showed progressive healing of periradicular lesions and root formation which confirmed the effectiveness of triple antibiotic paste in treatment of immature apical periodontitis.