DOI: 10.1002/ana.26780 ISSN:

Risk of Parkinson's disease in celiac disease: A Swedish population‐based study

Xiaoying Kang, Alexander Ploner, Bjorn Roelstraete, Jonas F. Ludvigsson, Karin Wirdefeldt
  • Neurology (clinical)
  • Neurology

Using a population‐based matched cohort design, we assessed the association of celiac disease (CeD) with risk of PD by comparing patients with biopsy‐confirmed CeD in Sweden to a biopsy‐free population and their unaffected siblings, separately. No overall association was observed but CeD diagnosed before age 60 associated positively with incident diagnosis of PD (HR = 1.29; 95% CI: 1.02–1.62), which was mainly attributed to the significantly elevated risk detected after 10–15 years since biopsy (HR = 1.68; 95% CI: 1.05–2.68). Our findings imply an increased vulnerability to long‐term PD development among patients with CeD diagnosed before 60s.

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