DOI: 10.1021/acs.joc.6c01873 ISSN: 0022-3263
Rh(III)-Catalyzed Direct C7 Alkylation of Indolines with Nitroalkenes
Shuang-Liang Liu, Jiejie Wang, Lin Liu, Kaixin Cheng, Hao-Ran Yang, Liming ZhouAbstract
The Rh(III)-catalyzed C7-alkylation of indolines with nitroalkenes under an ambient atmosphere is disclosed, affording diverse 7-(2-nitroalkyl)indolines with excellent chemo- and regioselectivity. The directing group is readily removable, and the resulting products can be oxidized to deliver 7-(2-nitroalkyl)indoles. Moreover, a plausible mechanism is proposed on the basis of control experiments.