Retinal vasculature changes after 0.125% atropine treatment in children with myopia measured using optical coherence tomography angiography: A pilot study
Yao-Chi Huang, Lan-Hsin Chuang, Ling Yeung, Hung-Chi Chen, Tsung-Hsien Tsai, Nan-Kai Wang, Po-Chun Chang, Yih-Shiou Hwang, Wei-Chi Wu, Chi-Chun Lai, Chun-Fu LiuAbstract:
Purpose:
The study assessed the microvascular changes in the retina after the use of 0.125% atropine in children with myopia and the association between retinal microvascular changes and the effects of myopia treatment.
Materials and Methods:
This is a prospective cohort study. Children with myopia aged 5–18 years old were included in the study. Retina microvascular parameters were measured with spectral domain optical coherence tomography (OCT) and OCT angiography devices during the follow-up. The main outcome measurements include vessel density of the superficial vascular plexus (SVP), deep vascular plexus, and axial length (AL).
Results:
A total of 64 eyes of 36 patients were included. A significant decrease in parafoveal vessel density of the SVP was observed in the first 3 months (
Conclusion:
These results suggest that 0.125% atropine might induce changes in the retina vasculature in children with myopia and that these changes might correlate with myopia progression. Nevertheless, as a pilot study, this result may need to be confirmed in larger studies.