DOI: 10.1093/brain/awag273 ISSN: 0006-8950
Rethinking multiple sclerosis therapy beyond clinical phenotypes
Maria Pia Sormani, Heinz Wiendl, Xavier Montalban, Jiwon OhSormani et al. argue that multiple sclerosis should be viewed as a biological continuum rather than distinct clinical forms. Evidence from recent trials suggests that therapies targeting shared biological mechanisms can slow disability progression across the disease spectrum, supporting a shift away from traditional classifications.