Resveratrol‐Loaded Fe‐Pt@UiO‐66‐NH ₂ Nanoformulation With pH‐Triggered Release and ROS Generation for Synergistic Anticancer and Antibacterial Therapy

ABSTRACT

Preventing wound infections and postoperative tumor recurrence remains challenging due to bacterial infection risks and potential cancer cell metastasis. Here, we developed a multifunctional drug‐loaded nanoformulation (RES@Fe‐Pt@MOF) based on UiO‐66‐NH ₂ doped with Fe‐Pt nanoparticles. The formulation was prepared by incorporating Fe‐Pt NPs via a solvothermal method, followed by resveratrol (RES) loading. It exhibits good stability, high RES loading capacity (26.9%), and excellent pH‐responsive release (17.59%, 34.0%, and 62.6% over 72 h at pH 7.4, 6.0, and 5.0, respectively). In vitro cell studies confirm good biocompatibility, effective killing of HepG2 cells, and suppression of cancer cell growth and migration. Antibacterial assays show that the formulation damages the surface morphology of E. coli and S. aureus by enhancing reactive oxygen species (ROS) generation, leading to potent sterilization. Consequently, the pH‐responsive RES@Fe‐Pt@MOF nanoformulation demonstrates superior antimicrobial and anticancer activities under mildly acidic conditions, highlighting its potential for postoperative cancer therapy.