Research Trends in Injinho and <i>Injinho-tang</i> for Hepatobiliary Disorders: A 15-Year Review

Objectives: Injinho has been widely used for hepatobiliary diseases, but comprehensive analyses of research trends across countries remain limited.Methods: A literature review was conducted across 10 databases from China, Korea, Japan, and Taiwan for studies published between January 1, 2011, and December 31, 2025, following PRISMA 2020 guidelines. A total of 428 studies were included and analyzed by country, study type, intervention, and disease category.Results: Among 428 included studies, 383 were conducted in China. Preclinical studies, particularly animal studies, predominated. Injinho research was mainly preclinical, whereas <i>Injinho-tang</i> research showed a more balanced distribution of clinical and preclinical studies. Cholestasis/obstructive jaundice and hepatitis were most frequently studied, with considerable research on NAFLD/NASH. Quality control and phytochemical studies were common, while clinical efficacy and mechanistic studies remained limited.Conclusions: Research on Injinho was predominantly conducted in China and was largely preclinical, particularly for single-herb studies, whereas <i>Injinho-tang</i> showed a more balanced clinical-preclinical distribution. These findings highlight the need for broader multinational and clinical research, along with continued efforts toward standardization of herbal materials and quality control, to strengthen the clinical evidence base.