Research on the Synthesis and Properties of Dodecyl/Tetradecyl Dimethyl Benzyl Ammonium Chloride Based on Microchannel Continuous Flow Technology

ABSTRACT

This study aims to develop an efficient and controllable microchannel continuous‐flow synthesis process for dodecyl/tetradecyl dimethyl benzyl ammonium chloride (12/1427), verifying the feasibility of replacing conventional reactors with microchannel technology. A continuous flow synthesis system was constructed using a separation‐recombination type micro‐mixer, with dodecyl/tetradecyl dimethyl tertiary amine and benzyl chloride serving as the raw materials. The optimal reaction conditions were a temperature of 50°C, a flow rate of 5 mL min ⁻¹ , a molar ratio of 1:0.985, and a coil length of 3 m, the tertiary amine conversion reached 96.61%, the yield was 96.21%, the active substance content of the product was 45%, the free amine content was 1%, and the pH value of the 10% aqueous solution was 6.8. The critical micelle concentration (CMC) of the product was 0.98 g L ⁻¹ , and the corresponding surface tension (γ _CMC ) was 33.62 mN m ⁻¹ . Its antistatic performance was comparable to that of industrial products. At a concentration of 50 ppm, both the microchannel product and the industrial product showed excellent bactericidal and bacteriostatic effects, with bactericidal and bacteriostatic rates exceeding 99.98%. The above results confirm that the microchannel continuous‐flow process is feasible for the production of 12/1427.