DOI: 10.1039/d6fo02488b ISSN: 2042-6496

Reply to the ‘Comment on “The overlooked impact of background diet and adherence in nutrition trials”’ by J. Lessard-Lord, C. Manach, L. Brennan, Y. Desjardins and J.-P. Drouin-Chartier, Food & Function

J. I. Ottaviani, H. Schroeter, D. M. Bier, J. W. Erdman, H. D. Sesso, J. E. Manson, G. G. C. Kuhnle

We address concerns regarding inter-individual differences in flavanol metabolism and biomarker levels and explain why they do not affect the conclusions of our study of the impact of background diet and adherence on the outcomes analysis of COSMOS.