Remission of Immunoglobulin A nephropathy following sequential tonsillectomy and appendectomy: A case report

Immunoglobulin A nephropathy is a common glomerular disease associated with mucosal immune dysregulation. We report the case of a young woman diagnosed with biopsy-proven immunoglobulin A nephropathy who achieved sustained clinical remission following sequential tonsillectomy and appendectomy performed for standard clinical indications. Tonsillectomy was associated with improvement in hematuria, whereas proteinuria persisted. Four years later, appendectomy for chronic appendicitis was followed by complete resolution of the proteinuria. The temporal association between these interventions and changes in disease activity is notable; however, causality cannot be established. This case highlights the potential relevance of extrarenal mucosal inflammatory conditions in selected patients with immunoglobulin A nephropathy and underscores the complexity of disease activity assessment. These observations should be considered hypothesis-generating and require further investigation.