Remarkable Advances of Indolylphosphine Ligands in Palladium Catalysis

Indolylphosphines have proven to be highly versatile ligands for palladium-catalyzed cross-coupling reactions. This short review covers the major developments in this area from mid 2015 to early 2026, emphasizing how recent innovations in ligand design have substantially improved reaction efficiency, expanded the scope of compatible coupling partners, and enabled challenging transformations under milder conditions. Structural motifs responsible for enhanced catalytic activity are highlighted, underscoring the ongoing impact of indolylphosphines in advancing cross-coupling methodology.