DOI: 10.3390/ijms25052800 ISSN: 1422-0067
Regulation of Disease-Resistance Genes against CWMV Infection by NbHAG1-Mediated H3K36ac
Aizhu Tu, Mila Wu, Yaoyao Jiang, Lidan Guo, Yunfei Guo, Jinnan Wang, Gecheng Xu, Jingjing Shi, Jianping Chen, Jian Yang, Kaili Zhong- Inorganic Chemistry
- Organic Chemistry
- Physical and Theoretical Chemistry
- Computer Science Applications
- Spectroscopy
- Molecular Biology
- General Medicine
- Catalysis
Post-translational modification of proteins plays a critical role in plant–pathogen interactions. Here, we demonstrate in Nicotiana benthamiana that knockout of NbHAG1 promotes Chinese wheat mosaic virus (CWMV) infection, whereas NbHAG1 overexpression inhibits infection. Transcriptome sequencing indicated that a series of disease resistance-related genes were up-regulated after overexpression of NbHAG1. In addition, cleavage under targets and tagmentation (Cut&Tag)-qPCR results demonstrated that NbHAG1 may activate the transcription of its downstream disease-resistance genes by facilitating the acetylation level of H3K36ac. Therefore, we suggest that NbHAG1 is an important positive regulator of resistance to CWMV infestation.