DOI: 10.1039/d6nr00636a ISSN: 2040-3364
Redox-responsive polymeric nanocarriers for targeted delivery of bruceantin to pancreatic cancer
Yitayal Admassu Workie, Kongbrailatpam Shitaljit Sharma, Vladislav Grigoriev, Yoon Tae Goo, Prem Singh, Ana Paula Mesquita Souza, Karthickraja Duraisamy, Akshay Vyawahare, Constanze Raitmayr, Neera Yadav, Chao Wang, Olena R. Taratula, Oleh TaratulaA redox-responsive, LHRH-targeted nanocarrier selectively delivered Bruceantin (BCT) to pancreatic tumors, where glutathione-triggered drug release enhanced antitumor efficacy while minimizing off-target accumulation.