Recyclable Magnetic Cu‐MOF‐74‐Catalyzed C–N Coupling and Cyclization for Synthesis of Azole‐ and Indole‐Fused Quinazolines or Pyrimidines

ABSTRACT

An improved methodology for synthesis of benzimidazole‐fused quinazolines and pyrimidines was developed by recyclable magnetic Cu‐MOF‐74‐catalyzed nucleophilic aromatic/vinylic substitution and cyclization of 2‐(2‐bromoaryl/vinyl)azoles and indoles with 2‐aminoazoles. The reaction could apply to a wide scope of starting materials containing electron‐donating or ‐withdrawing substituents on bromophenyl and azole/indole moieties. The catalyst could be recovered and reused up to four times without significant loss of catalytic activity.