Outline
DOI: 10.1039/d6md00337k ISSN: 2632-8682
Recent advances in scaffold-based KRAS G12C inhibitors: SAR and biological evaluation insights
Tomojit Bhattacharjee, Ankush Kumar, Thakur Gurjeet Singh, Rohit BhatiaThis review highlights recent scaffold-based KRAS G12C inhibitors, focusing on covalent Cys12 targeting, structure-guided optimization, SAR insights, and promising in vitro and in vivo anticancer activity.
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