Reactive angiomatosis secondary to chronic mechanical pressure: A two-patient case series: A case report

Continuous positive airway pressure (CPAP) is commonly associated with pressure-related cutaneous complications; however, reactive angiomatosis secondary to chronic CPAP mask use has not previously been reported. We present two 65-year-old men with slowly progressive, asymptomatic facial lesions localized to areas of chronic CPAP mask contact, with histopathologic findings demonstrating reactive vascular remodeling and clinicopathologic correlation supporting reactive angiomatosis, including diffuse dermal angiomatosis in one patient. In both patients, lesion distribution closely corresponded to sites of CPAP mask pressure. These cases expand the spectrum of CPAP-associated cutaneous complications and highlight chronic mechanical pressure and altered local vascular dynamics as a potential mechanism for reactive angiomatosis.