Outline
DOI: 10.1039/d6ra08647k ISSN: 2046-2069
Rational design and synthesis of furan-based Schiff base quinazolin-4-amine hybrids: spectral elucidation, molecular docking, DFT studies, and in silico ADMET-antioxidant study
Sunil D. Narode, Miral Vora, Jay B. Maheta, Yogesh O. Bhola, Darshna K. Lakhnotra, Nikita J. PatelFuran-based quinazolin-4-amine hydrazone hybrids (4a–h) were synthesized in 84–90% yields. DFT, Keap1 docking and ADMET supported the scaffold. Compounds showed superior DPPH antioxidant activity to ascorbic acid, with 4d and 4f most active.
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