Rare Gallbladder Carcinoma: A Case Report on Squamous Cell Carcinoma of the Gallbladder

Squamous cell carcinoma (SCC) of the gallbladder is a rare and aggressive subtype that typically presents at an advanced stage and carries a poor prognosis, often with median survival under 1 year. Risk factors reflect those of other gallbladder cancers—chronic cholecystitis, gallstones, and female sex. Diagnosis is frequently made intra‐ or postoperatively via histopathological biopsy. Surgical resection is the primary treatment, but curative intervention is often unachievable due to extensive disease at presentation. We describe a 59‐year‐old woman with fevers, aches, chills, night sweats, nausea, and vomiting with imaging suggestive of a liver abscess with fistulous connection to the gallbladder. Exploratory laparotomy revealed poorly differentiated, nonkeratinizing SCC with sarcomatoid features; immunohistochemistry was positive for CK5/6, p40, and CK7. Understanding the molecular mechanisms for the progression of SCC of the gallbladder could help target interventions. Given its rarity, standardized adjuvant treatment guidelines are lacking—highlighting the need for further molecular and therapeutic research.