DOI: 10.1002/ccr3.73230 ISSN: 2050-0904
Rare Coexistence of Familial Laryngo‐Onycho‐Cutaneous Syndrome (
LOCS
/Shabbir Syndrome) and Epidermolysis Bullosa With Multisystemic Involvement: A Case Series
Zainab Rasheed, Muhammad Rashid, Usman Syed Mahmud, Muhammad Hassaan Javaid, Raghabendra Kumar Mahato, Zubaria Yaqoob ABSTRACT
The coexistence of LOCS and a broader EB phenotype within a single consanguineous family represents a unique instance of intra‐familial phenotypic heterogeneity in LAMA3‐related junctional epidermolysis bullosa. This highlights the importance of recognizing systemic manifestations, including urological and neurological complications, and underscores early diagnosis, multidisciplinary management, and genetic counseling.