Racing Against Rarity: A Unique Case of Mesonephric Adenocarcinoma of the Cervix in a 35-Year-Old Female
Arpana Kulkarni, Sushama Gurwale, Mangesh Machindra Londhe, Shivani Sunil Dhondge
A
BSTRACT
Mesonephric adenocarcinoma of the uterine cervix is a rare, human papillomavirus-independent malignancy arising from mesonephric duct remnants and is often underrecognized due to its varied morphology and resemblance to other cervical adenocarcinomas. We report a case of a 35-year-old woman presenting with abnormal uterine bleeding. Imaging revealed a cervical lesion, and biopsy suggested adenocarcinoma. Following radical hysterectomy, histopathology showed an infiltrative tumor composed of glands and tubules with focal retiform architecture and intraluminal eosinophilic secretions. Immunohistochemistry demonstrated positivity for CK7, PAX8, GATA3, and luminal CD10, with nonblock-type p16 staining, confirming mesonephric differentiation. This case underscores the importance of careful morphologic evaluation and appropriate immunohistochemical analysis for accurate diagnosis of this uncommon but clinically significant cervical malignancy.