DOI: 10.1039/d6ra06124a ISSN: 2046-2069
Quinazolinone–triazole hybrids as multi-target-directed ligands for Alzheimer's disease: discovery of potent and selective MAO-B inhibitors with cholinesterase modulating activity
Wagdy M. Eldehna, Ashraf K. El-Damasy, Jaeyeop Lim, Salma M. Hefny, Tarfah Al-Warhi, Amal S. Elgohary, Anwar A. El-Hamaky, Man-Jeong Paik, Mohamed R. Elnagar, Diaaeldin M. Elimam, Yasser M. Omar, Hoon Kim, Haytham O. TawfikA new series of quinazolinone–triazole hybrids (QTHs, 5a–n) was designed, synthesized, and evaluated as potential multi-target-directed ligands for Alzheimer's disease.