DOI: 10.1002/cpt.70531 ISSN: 0009-9236
Quantitative Sciences in the Model‐Informed Era: From Parallel Functions to a Shared Decision System
Avery McIntosh, Mohamed Elmeliegy, Jeffrey P. Palmer, Nikolaos Tsamandouras, Vaishali Sahasrabudhe, Blerta ShtyllaModel‐informed drug development increasingly depends on collaboration among clinical pharmacology, statistics, pharmacometrics, and quantitative systems pharmacology. Yet functional silos, distinct leadership structures, and divergent goals can reduce collaboration to late, parallel deliverables that constrain decision architecture. This Perspective defines a shared decision system as an operating model in which quantitative and clinical disciplines jointly define the question, context of use, evidentiary role, uncertainty standards, and accountability for model‐informed evidence.