Quantitative MRI Susceptibility: Mapping of Transient Ischemic Attack—A Preliminary Study

A transient ischemic attack (TIA) is a transient episode of neurological dysfunction without evidence of acute infarct demarcation on neuroimaging. The radiographic features of TIAs are uncertain, as since there is currently no perfect imaging method with which to differentiate a stroke from a TIA. We aimed to evaluate whether regional abnormalities are associated with TIA by identifying tissue with increased susceptibility (χ) values using quantitative susceptibility mapping (QSM). A total of 39 adults with clinical TIA symptoms (66 ± 12 years) and 39 age- and sex matched controls (65 ± 12 years) underwent MRI. Based on the QSM-maps, local susceptibility changes were tested for statistically significant differences between patients with TIA and healthy controls. The susceptibility maps of TIA patients showed that magnetic susceptibility differed from that of healthy volunteers, with the strongest effects observable in the right lingual gyrus (p < 0.001) and bilaterally in the caudal anterior cingulate (cACC, p < 0.01). TIA is often difficult to diagnose at the time of presentation in the emergency department, and QSM could show an association between regional QSM abnormalities and TIA.