DOI: 10.1039/d6np00044d ISSN: 0265-0568
Pyrrocidines and hirsutellones: distinctive fungal polyketide alkaloid hybrids with intriguing therapeutic applications: a comprehensive update
Mohamed A. Tammam, Islam El-Awaad, Adnane Aouidate, Reham Hassan Mekky, Amr El-DemerdashFungal pyrrocidines and hirsutellones are distinctive PKS-NRPS hybrids. This review examines their diversity, biosynthesis, bioactivity, pharmacokinetics and SARs, with emphasis on antimicrobial and anticancer potential.