Pulsed NIR‐II Activated Arsenic‐Doped Black Phosphorus for Pyroelectric Dynamic Therapy‐Chemotherapy Synergistic Tumor Treatment
Chen‐Chen Fu, Zhen Song, Zi‐Chao Yan, Qi‐Kun Zhang, Tian‐Kun Hui, Tian‐Qi Zhang, Chen Wang, Ke‐Bing Wu, Shuo Wang, Han‐Tao Ruan, Jian‐Lei Xie, Meng QiuABSTRACT
Pyroelectric materials can generate an internal electric potential under temperature fluctuations, sustaining charge separation for reactive oxygen species (ROS) production. Black phosphorus (BP) is attractive for photonic therapy due to its intrinsic photothermal and pyroelectric properties, yet its translation is limited by poor physiological stability, insufficient temperature transients under continuous irradiation, limited tissue penetration, and intratumoral glutathione (GSH) that quenches oxidative stress. Here, we develop a two‐dimensional arsenic‐doped BP (AsP) nanosheet platform enabled by a “composition‐excitation” engineering strategy for 1064 nm pulsed NIR‐II‐triggered pyroelectric dynamic therapy (PEDT) synergized with arsenic chemotherapy. Arsenic doping enhances lattice asymmetry, improving stability and pyroelectric output. Pulsed excitation provides deep‐tissue activation and rapid thermal transients, maximizing pyroelectric‐driven ROS while minimizing thermal accumulation. ROS further accelerates controlled AsP degradation to release arsenic species that deplete GSH and suppress mitochondrial ATP production, establishing a redox‐energy co‐disruption loop. The platform achieves >98% tumor growth inhibition with favorable biocompatibility in a solid‐tumor model.