DOI: 10.1001/jamapsychiatry.2026.2733 ISSN: 2168-622X

Psilocybin and Inflammatory and Mitochondrial Stress Markers in Parkinson Disease

Ellen R. Bradley, Parker Kelley, Balázs Szigeti, Kristen Nishimi, Martin Picard, Kimberly Sakai, Gisele Fernandes-Osterhold, Jill L. Ostrem, Caroline M. Tanner, Connie Ludwig, Katiah Llerena, Patrick R. Finley, Zachary Busby, Amber McKernan, Madeline Marie Pantoni, Andrew D. Penn, Aliss C. C. Wang, Jose Rafael Pantoja Zuzuarregui, Joshua D. Woolley, Aoife O’Donovan

This nonrandomized clinical trial assesses associations between psilocybin therapy and changes in systemic markers of inflammation and mitochondrial stress in people with Parkinson disease and mood dysfunction.

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