DOI: 10.1039/d6mh01182a ISSN: 2051-6347
Programmable cross-activity of catalase via functional state engineering in a uricase–catalase cascade nanogel
Manting Jin, Guangce Yuan, Qiao Zhao, Haojie Yang, Yuting Guo, Yujing Tang, Mingyue Shi, Qing Wu, Lehang Guo, Qigang Wang, Xia WangThis study reports a dynamic, state-centric strategy for regulating catalase switching via localized substrate flux, yielding a cascading enzyme nanogel (Gel@UOx/CAT) that clears urate crystals and ROS for adaptive biocatalytic therapy.