DOI: 10.32322/jhsm.2016244 ISSN: 2636-8579

Prognostic value of the HALP score in primary IgA nephropathy: association with adverse renal outcomes

Hatice Şahin, Gülay Ulusal Okyay, Fatma Ayerden Ebinç, Emre Yaşar, Ebru Gök Oğuz, Merve Şanlıer, Muzhgan Guliyeva, Berrak Itır Aylı, Ebru Şebnem Ayva, Arzu Sağlam Ayhan, Mehmet Deniz Aylı
Show PDF Cite
Aims: The hemoglobin-albumin-lymphocyte-platelet (HALP) score is a composite biomarker reflecting systemic inflammation and nutritional status. However, its prognostic significance in immunoglobulin A nephropathy (IgAN) remains insufficiently explored. This study aimed to evaluate the renal prognostic value of inflammatory and nutritional indices, including the HALP score, measured at the time of kidney biopsy in patients with IgAN.Methods: The study cohort included 171 adult patients with biopsy-proven primary IgAN diagnosed between 1 January 2015 and 15 April 2025, with at least 12 months of follow-up unless the composite renal endpoint occurred earlier. Poor prognosis was defined as the occurrence of the primary composite endpoint: a ≥50% decline in estimated glomerular filtration rate from baseline or initiation of renal replacement therapy. Multivariable logistic regression, Kaplan-Meier survival, and receiver operating characteristic (ROC) curve analyses were performed to identify factors associated with poor renal prognosis. Results: During a median follow-up of 25.4 months, 45 patients (26.3%) reached the composite renal outcome. In the multivariable logistic regression analysis, each 10-unit increase in HALP was independently associated with lower odds of poor renal prognosis [odds ratio (OR), 0.78; 95% confidence interval (CI), 0.62-0.99; p=0.040]. Kaplan-Meier survival analysis demonstrated significantly lower event-free survival in the low-HALP group (log-rank p

More from our Archive