DOI: 10.1177/11795549261500589 ISSN: 1179-5549

Prognostic Significance of Gastric Fluid RGS1 and COL4A1 Levels in Gastric Cancer Patients

Junli Wang, Pei Gu, Xiaolei Niu, Hailing Zhang, Zhengrong Guo
Show PDF Cite

Objective

To investigate the predictive value of gastric fluid levels of Regulator of G-protein Signaling 1 (RGS1) and Collagen Type IV Alpha 1 Chain (COL4A1) for prognosis in patients with gastric cancer.

Methods

From January 2021 to May 2022, 240 patients who underwent radical gastrectomy for gastric cancer were prospectively enrolled in this single-center prospective observational study and followed up for 3 years. Patients were categorized into a poor-prognosis group (n=68) and a good-prognosis group (n=172) based on follow-up outcomes. Gastric fluid RGS1 and COL4A1 levels were measured by enzyme-linked immunosorbent assay. Spearman correlation, receiver operating characteristic (ROC) curve, Kaplan–Meier, and multivariable Cox proportional hazards regression analyses were performed.

Results

The poor-prognosis group exhibited a higher TNM stage, greater depth of invasion, and a higher rate of lymph node metastasis (all P < 0.05). RGS1 and COL4A1 levels were elevated in the poor-prognosis group; the two markers were positively correlated (r = 0.319, P < 0.05). ROC curve analysis showed areas under the curve of 0.852 and 0.838 for RGS1 and COL4A1 alone, respectively, with a combined area under the curve of 0.878. Kaplan–Meier analysis indicated significantly shorter mean survival time in the high-expression groups (log-rank χ 2 = 119.98 and 69.73, respectively; both P < 0.001). Multivariable Cox regression identified higher TNM stage, depth of invasion, lymph node metastasis, elevated RGS1 (hazard ratio [HR] = 1.064, 95% confidence interval [CI]: 1.040–1.088, per 100 pg/mL), and elevated COL4A1 (HR = 1.492, 95% CI: 1.221–1.822, per 100 pg/mL) as independent risk factors for poor prognosis (all P < 0.05).

Conclusions

Elevated gastric fluid RGS1 and COL4A1 levels are closely associated with poor prognosis in gastric cancer, suggesting their potential exploratory value as adjunctive indicators for prognostic stratification; however, their clinical applicability remains to be validated.

More from our Archive