Prognostic impact of zinc deficiency on clinical outcomes in patients with chronic limb-threatening ischemia following endovascular therapy
Y Ikeuchi, T Toyoshima, H Minamiguchi, Y Ichibori, K Nakamoto, N Mori, T Kanda, T Tsujimura, Y Okina, H Tsutsui, M Matsumura, S Nakawatase, T Sakio, D Yoshii, O IidaAbstract
Background
Zinc (Zn) is an essential trace element known to reduce atherosclerotic risk and play a critical role in immune function and wound healing. While its importance is recognized in various cardiovascular conditions, the specific impact of Zn deficiency on outcomes in patients with chronic limb-threatening ischemia (CLTI), the most severe form of peripheral artery disease, remains poorly understood following endovascular therapy (EVT).
Purpose
This study aimed to investigate the prognostic impact of Zn deficiency on clinical outcomes of CLTI patients with tissue loss following EVT.
Methods
In this single-center retrospective study, we analyzed 313 consecutive patients with CLTI (mean age: 77.9 ± 9.3 years; male: 58.6%, dialysis: 36.1%) who underwent EVT between April 2023 and January 2026 and had serum Zn levels measured at baseline. Zinc deficiency was defined as a serum Zn level < 60 µg/dL based on the median level. The outcome measure was amputation-free survival. Kaplan-Meier analysis and Cox proportional hazards models were used for statistical analysis.
Results
Zinc deficiency was present in 144 patients (46.0%). On baseline comparison, patients with Zn deficiency exhibited a significantly higher prevalence of body mass index (BMI) <18.5 kg/m2 (25.9% vs 15.5%), serum albumin level <3.0 g/dL (42.0% vs 11.4%), and WIfI stage 4 (49.3% vs 29.2%), and had a significantly lower prevalence of non-ambulatory status (41.3% vs 62.5%), dyslipidemia (42.4% vs 54.4%), statin therapy (38.9% vs 58.9%), coronary artery disease (29.9% vs 42.0%), and smoking history (33.3% vs 46.2%) compared to those without deficiency (all p < 0.01). Consistent with this, multivariate logistic regression analysis revealed that serum albumin < 3.0 g/dL was the strongest independent predictor of Zn deficiency (odds ratio [OR] 4.08, 95% confidence interval [CI] 2.19–7.60, p < 0.001). Kaplan–Meier analysis demonstrated that patients with Zn deficiency had significantly worse 1-year AFS compared to those without deficiency (77.9% versus 63.3%, log-rank p=0.002).
Conclusion
The current study revealed that zinc deficiency is prevalent among patients with CLTI and identifies a subgroup with poorer nutritional status. It serves as a robust marker for worse amputation-free survival. Our findings suggest that assessing serum zinc levels could help stratify risk in this high-risk population.For image description, please refer to the figure legend and surrounding text.For image description, please refer to the figure legend and surrounding text.