Prevalence, clinical features, and treatment pattern of patients with coexistence of lupus erythematosus and psoriasis: A retrospective study in a single center in Taiwan
Ting-Ting Cheng, Kun-Hung Chen, Kah-Hau Kwong, Yang LoAbstract
Background:
Patients with systemic lupus erythematosus (SLE) are at increased risk of developing additional autoimmune disorders. The coexistence of SLE and psoriasis (PSO) is rare but may pose diagnostic and therapeutic challenges.
Objectives:
This study aimed to compare patients with coexisting SLE and PSO with those having SLE alone in a Taiwanese cohort.
Methods:
We conducted a retrospective, single-center study from 2007 to 2023, identifying patients diagnosed with both SLE and PSO. Clinical features, laboratory profiles, treatment patterns, and comorbidities were analyzed.
Results:
A total of 12 patients with coexisting SLE and PSO were identified, yielding a prevalence of 1.5% among patients with SLE. Plaque PSO was the predominant subtype, and the disease was mild in most cases. Compared to the SLE-only group, the coexistence group had a higher proportion of males. No significant differences were observed in typical lupus manifestations or most laboratory parameters, except for a lower frequency of reduced complement levels in the coexistence group. No additional cardiovascular risk was identified.
Conclusion:
This single-center study highlights the clinical, laboratory, and treatment characteristics of patients with coexisting SLE and PSO in Taiwan and provides insight into this rare overlap condition.