DOI: 10.32322/jhsm.1945191 ISSN: 2636-8579

Predictive role of the de Ritis ratio in mortality prediction of COVID-19 patients in intensive care unit: a single-center cohort study

Ayşenur Uçar, Fatih Eskin, Eylem Gül Ateş, Mehmet Erdevir, Felemez Arslan
Show PDF Cite
Aims: The aim of this study is to evaluate the role of De Ritis ratio in predicting intra-hospital mortality in patients treated in intensive care unit (ICU) due to coronavirus disease 2019 (COVID-19). The De Ritis ratio is calculated using the formula: aspartate aminotransferase (AST)/alanine aminotransferase (ALT).Methods: Data from 414 patients admitted to the ICU with a diagnosis of COVID-19 at a single-center between March 2020 and March 2022 were retrospectively analyzed. Patients were divided into two groups: survivors and deceased patients. Demographic, clinical, and laboratory data of the patients were compared. Between-group comparisons were performed using the Mann-Whitney U test for continuous variables and Chi-square or Fisher’s exact tests for categorical variables, as appropriate. The performance of the De Ritis ratio in predicting mortality was evaluated using ROC curves, the Youden Index and APACHE-inclusive sensitivity model. Model discrimination was assessed using AUC with bootstrap 95% confidence intervals, calibration using the Brier score and Hosmer-Lemeshow test, multicollinearity using variance inflation factors, and internal validation using bootstrap optimism correction.Results: Of the 414 patients, 211 (51.0%) died. The De Ritis ratio was higher among non-survivors than survivors [median 1.61 (IQR 1.14-2.28) vs 1.17 (IQR 0.86-1.61), p

More from our Archive