DOI: 10.69601/meandrosmdj.1799178 ISSN: 2149-9063

Potential Role of Salvia Officinalis (Sage) in Oral Health: an In Vitro Study on Its Antibacterial Effects

Gülşah Altan, Devrim Dündar
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Aim: This study aimed to investigate the antimicrobial effects of methanolic leaf and root extracts of S. officinalis against bacteria isolated from the oral microbiota and to evaluate its potential therapeutic use in oral health. Materials and Methods: Plant samples were collected from the Nif Mountain region in İzmir, Turkey, and extracted using methanol. Oral bacteria were isolated from healthy individuals and identified by the Vitek MS system. Antimicrobial susceptibility was tested using the broth microdilution method to determine minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC). Results: Streptococcus sanguinis, S. mitis, S. salivarius, S. vestibularis, Rothia aeria, R. mucilaginosa, Neisseria flava, N. subflava, N. cinerea, N. mucosa, Gemella haemolysans strains were isolated from the oral cavity. Minimum inhibitory concentration (MIC) values are between 7.8-500 µg/ml in leaf extracts and 15.6-500 µg/ml in root extracts. The lowest MIC value of leaf extracts was 7.8 µg/ml in S. mitis, N. mucosa and the lowest MIC value of root extracts was detected as 15.6 µg/ml in N. mucosa, N. flava, N. cinerea. Conclusion: Although there is no standard method in antimicrobial susceptibility tests performed with plant extracts, the results of this study show that S. officinalis leaf and root extracts may have an antibacterial effect against Streptococcus, Rothia and Neisseria species and, it can be used for protecting oral and dental health, preventing infections caused by these bacteria and support treatment of this bacteria.

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