Potential role of resveratrol in promoting transcription factor 7-like 2 gene expression and dyslipidaemia in type II diabetic rats
Zinah Mohammed Al-Shammri, Shatha Qasim JabarObjectives:
The study was designed to explore the possible action of resveratrol (RES) on transcription factor 7-like 2 ( TCF7L2 ) gene expression and its effect on lipid profile in type II diabetes mellitus (T2DM) rats.
Materials and Methods:
Thirty-two male Wistar rats were randomly assigned into four groups. Diabetes was induced in Group 1 through alloxan and nicotinamide. Group 2 was diabetic, and Group 3 was a non-diabetic control which received RES too. The researchers evaluated blood glucose (BG) and lipid profile (total cholesterol [TC], triglycerides [TG], high-density lipoprotein [HDL] and low-density lipoprotein [LDL]) at 28 days. Liver TCF7L2 gene expression was measured in parallel.
Results:
Group 1 achieved successful diabetes induction, as evidenced by significantly reduced TCF7L2 gene expression and HDL levels, and increased BG, TC, TG and LDL ( P < 0.05). However, both of the RES-treated groups (Groups 2 and 3) showed astounding enhancements. Over the last few weeks, they showed an upwards trend in HDL and TCF7L2 gene expression, as well as a downwards trend in BG, TC, TG and LDL ( P < 0.05).
Conclusion:
Diabetes impaired metabolism, and RES ameliorated these effects. RES modulated expression of TCF7L2, and our data indicate that this can perhaps partly explain the anti-diabetic, antioxidant and metabolic benefits of RES. This study emphasises the potential of RES for therapeutic benefit in T2DM.