Potential protective role of moringa seeds nanosuspension against chemotherapy-induced delayed wound healing in albino rats
Sohila Mokhtar Mohamed Elkholy, Olfat M. Gaballah, Hasnaa Fouad, Mai B. HelalObjective
The aim of the present study was to evaluate the potential protective effect of nanosuspension of moringa seeds extract on accelerating wound healing of albino rats’ tongue during 5-fluorouracil (5-FU) systemic administration.
Materials and methods
This study included 60 adult male albino rats divided equally into three groups. Group I: rats underwent a tongue wound and left to heal spontaneously without treatment, group II: rats were subjected to tongue wounding followed by 5-FU injection intraperitoneally and left to heal spontaneously, and group III: rats in this group were treated similarly to group II in combination with oral administration of the nanosuspension of moringa seeds extract. The investigative techniques employed included light microscopy, transmission electron microscopy, and histomorphometric analysis utilizing P63 immunostaining. The outcomes were meticulously assessed on days 7 and 14 postwound induction.
Results
The results of this study showed that group III had significantly improved histological outcomes compared to group I and group II. Complete re-epithelialization was observed in group III on day 14, whereas group II exhibited partial healing. Quantitative analysis revealed a significant increase in P63-positive nuclei in group III (
Conclusion
Moringa seeds nanosuspension treatment demonstrated potential benefits for or̅al wound healing, accelerating the healing process delayed by 5-FU administration.