Polyphenols-rich Extract from Leaves of Moringa oleifera Ameliorates Diabetic Dyslipidemia by Regulating the Fatty Acid-synthesizing Genes
Aju Baburaj Yamuna, Rajalakshmi Radhakrishnan, Mini SaraswathyBackground:
Diabetic dyslipidemia, seen in type 2 diabetes, contributes to the development of cardiovascular diseases.
Materials and Methods:
The amount of serum glucose, tissue, and serum lipids, and the messenger ribonucleic acid (mRNA) expression of genes for fatty acid synthase (FAS), acetyl CoA carboxylase 1 (ACC1), and sterol regulatory element-binding protein 1c (SREBP1c) were analyzed. Phytochemical characterization of MOME by high-performance liquid chromatography (HPLC) and ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC qTOF MS) analysis showed the presence of cinnamic acid and gallic acid.
Results:
MOME exerts a significant modulatory effect on diabetic dyslipidemia. MOME supplementation to normal rats reduced the concentration of serum cholesterol and triglycerides. Its hypolipidemic action is mediated by downregulating the mRNA expression of the
Conclusion:
The flavonoids and phenolic acids-rich MOME impart a significant regulatory effect on diabetic dyslipidemia in rats. Its hypolipidemic action is by downregulating the mRNA expressions of